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Comparison of Weekly Paclitaxel Regimens in Recurrent Platinum-Resistant Ovarian Cancer: A Single Institution Retrospective Study.
Morin, Laurence; Grenier, Louis-Philippe; Foucault, Nicolas; Lévesque, Éric; Fabi, François; Langlais, Eve-Lyne; Sebastianelli, Alexandra; Lavoie, Marianne; Lalancette, Marc; Plante, Marie; Singbo, Mahukpe Narcisse Ulrich; Castonguay, Vincent.
Afiliación
  • Morin L; Medical Oncology Division, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1J 5B3, Canada.
  • Grenier LP; Medical Oncology Pharmacy Department, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1J 5B3, Canada.
  • Foucault N; Pharmacy Department, Unité de Formation et de Recherche en Santé de Rouen, 76183 Normandie, France.
  • Lévesque É; Medical Oncology Division, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1J 5B3, Canada.
  • Fabi F; Radio-Oncology Division, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1J 5B3, Canada.
  • Langlais EL; Gynecologic Oncology Division, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1J 5B3, Canada.
  • Sebastianelli A; Gynecologic Oncology Division, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1J 5B3, Canada.
  • Lavoie M; Medical Oncology Division, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1J 5B3, Canada.
  • Lalancette M; Medical Oncology Division, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1J 5B3, Canada.
  • Plante M; Gynecologic Oncology Division, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1J 5B3, Canada.
  • Singbo MNU; Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1E 6W2, Canada.
  • Castonguay V; Medical Oncology Division, Centre Hospitalier Universitaire de Québec-Université Laval, Québec, QC G1J 5B3, Canada.
Curr Oncol ; 31(8): 4624-4631, 2024 08 15.
Article en En | MEDLINE | ID: mdl-39195328
ABSTRACT
Weekly paclitaxel (WP) is a chemotherapeutic cornerstone in the management of patients with platinum-resistant ovarian carcinoma. Multiple WP dosing regimens have been used clinically and studied individually. However, no formal comparison of these regimens is available to provide objective guidance in clinical decision making. The primary objective of this study was to compare the cumulative dose of paclitaxel delivered using 80 mg/m2/week, administered using either a 3 weeks out of 4 (WP3) or a 4 weeks out of 4 (WP4) regimen. The secondary objective was to evaluate the clinical outcomes associated with both regimens, including efficacy and toxicity parameters. Our retrospective cohort comprised 149 patients harboring platinum-resistant ovarian cancer treated at the CHU de Québec from January 2012 to January 2023. WP3 and WP4 reached a similar cumulative dose (1353.7 vs. 1404.2 mg/m2; p = 0.29). No significant differences in the clinical outcomes were observed. The frequency of dose reduction was significantly higher for WP4 than WP3 (44.7% vs. 4.9%; p < 0.01), mainly due to treatment intolerance from toxicity (34.0% vs. 3.9%; p < 0.01). Our data suggest that a WP3 regimen delivers a similar cumulative dose to WP4, hence offering a better tolerability profile without compromising efficacy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Paclitaxel / Resistencia a Antineoplásicos Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Curr Oncol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Paclitaxel / Resistencia a Antineoplásicos Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Curr Oncol Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza