1,2-Amidoarylcarbonylation of Styrenes to Access ß-Acylamino Ketones by NHC-Catalyzed Radical Relay.
J Org Chem
; 89(18): 13085-13092, 2024 Sep 20.
Article
en En
| MEDLINE
| ID: mdl-39197017
ABSTRACT
An amidoarylcarbonylation reaction of aromatic aldehydes and olefins with Katritzky pyridinium salts by N-heterocyclic carbene (NHC)-catalyzed radical relay to construct C-C and C-N bonds with good functional group tolerance is developed for the synthesis of ß-acylamino ketones. This gentle and efficient approach offers a valuable style for the synthesis of ß-acylamino ketones. Mechanistic studies revealed that a radical addition/coupling/elimination cascade process was involved in this reaction.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Estados Unidos