Excitotoxic spinal damage induced by kainic acid impairs locomotion, alters nociception, and reduces CREB nuclear translocation.
Behav Brain Res
; 475: 115219, 2024 10 18.
Article
en En
| MEDLINE
| ID: mdl-39209120
ABSTRACT
Our previous in vitro studies showed that excitotoxicity evoked by glutamate analogue kainate (KA) significantly decreased the number of rat spinal neurons and triggered high release of glutamate leading to locomotor network block. Our current objective was to assess the role of CREB as a predictive marker of damage following chemically-induced spinal cord injury by using in vivo and in vitro models. Thus, in vivo excitotoxicity in Balb/c adult mice was induced by KA intraspinal injection, while in vitro spinal cord excitotoxicity was produced by bath-applied KA. KA application evoked significant neuronal loss, deterioration in hindlimb motor coordination and thermal allodynia. In addition, immunohistochemical analysis showed that KA application resulted in decreased number of CREB positive nuclei in the ventral horn and in dorsal layers III-IV. Our data suggests that excitotoxic-induced neuronal loss may be potentially predicted by altered CREB nuclear translocation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Médula Espinal
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Proteína de Unión a Elemento de Respuesta al AMP Cíclico
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Nocicepción
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Ácido Kaínico
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Ratones Endogámicos BALB C
Límite:
Animals
Idioma:
En
Revista:
Behav Brain Res
/
Behav. brain res
/
Behavioural brain research
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos