Mitochondrial transfer from mesenchymal stem cells: Mechanisms and functions.
Mitochondrion
; : 101950, 2024 Aug 30.
Article
en En
| MEDLINE
| ID: mdl-39218052
ABSTRACT
Mesenchymal stem cells based therapy has been used in clinic for almost 20â¯years and has shown encouraging effects in treating a wide range of diseases. However, the underlying mechanism is far more complicated than it was previously assumed. Mitochondria transfer is one way that recently found to be employed by mesenchymal stem cells to exert its biological effects. As one way of exchanging mitochondrial components, mitochondria transfer determines both mesenchymal stem cells and recipient cell fates. In this review, we describe the factors that contribute to MSCs-MT. Then, the routes and mechanisms of MSCs-MT are summarized to provide a theoretical basis for MSCs therapy. Besides, the advantages and disadvantages of MSCs-MT in clinical application are analyzed.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Mitochondrion
Año:
2024
Tipo del documento:
Article
País de afiliación:
China