Adventures with the ß2-adrenoceptor Receptor: A Career Long Interest in Agonising One of the Most Widely Studied GPCRs.
Chimia (Aarau)
; 78(7-8): 483-498, 2024 Aug 21.
Article
en En
| MEDLINE
| ID: mdl-39221844
ABSTRACT
Drug discovery is a multi-disciplinary effort in which groups with expertise in a range of areas combine in a unified way to achieve a common goal to deliver a clinical candidate to evaluate a hypothesis for improving human health. As a medicinal chemist this environment has provided multiple opportunities to be involved in cross-discipline interactions that have been both rewarding and led to outcomes that would not have been possible without an intimate interdisciplinary curiosity. Within this article I aim to share some of my experiences with the ß2-adrenoceptor that have fostered such synergistic relationships with several disciplines, but in particular with in vitro pharmacologists looking at different ways to stimulate this G protein-coupled receptor (GPCR). This interest now spans over a quarter of a century and has been intertwined with the delivery of three clinical candidates.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores Adrenérgicos beta 2
Límite:
Humans
Idioma:
En
Revista:
Chimia (Aarau)
/
Chimia (Basel)
Año:
2024
Tipo del documento:
Article
País de afiliación:
Suiza
Pais de publicación:
Suiza