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Novel Tubeimoside I liposomal drug delivery system in combination with gemcitabine for the treatment of pancreatic cancer.
Li, Shuhui; Liu, Yuansheng; Sui, Xiaojun; Zhuo, Yuzhen; Siqi, He; Sijia, Zhang; Hui, Zhang; Dihua, Li; Dapeng, Zhang; Lei, Yang.
Afiliación
  • Li S; School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
  • Liu Y; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, 300000, China.
  • Sui X; Tianjin Key Laboratory of Organ Injury and ITCWM Repair Associated with Acute Abdominal Diseases, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, 300100, China.
  • Zhuo Y; Graduate School ofTianjin Medical University, Tianjin, 300270, China.
  • Siqi H; Tianjin Key Laboratory of Organ Injury and ITCWM Repair Associated with Acute Abdominal Diseases, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, 300100, China.
  • Sijia Z; Graduate School ofTianjin Medical University, Tianjin, 300270, China.
  • Hui Z; Graduate School ofTianjin Medical University, Tianjin, 300270, China.
  • Dihua L; Tianjin Key Laboratory of Organ Injury and ITCWM Repair Associated with Acute Abdominal Diseases, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, 300100, China.
  • Dapeng Z; Tianjin Key Laboratory of Organ Injury and ITCWM Repair Associated with Acute Abdominal Diseases, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, 300100, China.
  • Lei Y; Tianjin Key Laboratory of Organ Injury and ITCWM Repair Associated with Acute Abdominal Diseases, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, 300100, China.
Nanomedicine (Lond) ; 19(24): 1977-1993, 2024.
Article en En | MEDLINE | ID: mdl-39225145
ABSTRACT

Aim:

To evaluate the anti-pancreatic cancer effect of novel Tubeimoside I multifunctional liposomes combined with gemcitabine.

Methods:

Liposomes were prepared through the thin film hydration method, with evaluations conducted on parameters including encapsulation efficiency (EE%), particle size, polydispersity index (PDI), zeta potential (ZP), storage stability, and release over a 7-day period. The cellular uptake rate, therapeutic efficacy in vitro and in vivo and the role of immune microenvironment modulation were evaluated.

Results:

The novel Tubeimoside I multifunctional liposomal exhibited good stability, significant anti-cancer activity, and immune microenvironment remodeling effects. Furthermore, it showed a safety profile.

Conclusion:

This study underscores the potential of Novel Tubeimoside I multifunctional liposomal as a promising treatment option for pancreatic cancer.
[Box see text].
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Sistemas de Liberación de Medicamentos / Desoxicitidina / Gemcitabina / Liposomas Límite: Animals / Humans Idioma: En Revista: Nanomedicine (Lond) Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Sistemas de Liberación de Medicamentos / Desoxicitidina / Gemcitabina / Liposomas Límite: Animals / Humans Idioma: En Revista: Nanomedicine (Lond) Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido