Lack of classical astroblastoma features in pediatric MN1::BEND2-fused brain tumors.

Chapman, Nicholas; Iqbal, Mohammed; Walker, Adam D; Hawes, Debra; Davidson, Tom Belle; Robison, Nathan; Tamrazi, Benita; Ji, Jianling; Krieger, Mark D; Cotter, Jennifer A

Chapman, Nicholas; Iqbal, Mohammed; Walker, Adam D; Hawes, Debra; Davidson, Tom Belle; Robison, Nathan; Tamrazi, Benita; Ji, Jianling; Krieger, Mark D; Cotter, Jennifer A.

Afiliación

Chapman N; Department of Surgery and Division of Neurosurgery, Children's Hospital Los Angeles, Los Angeles, California, USA.
Iqbal M; Department of Neurosurgery, University of Texas, Dell Medical School, Austin, Texas, USA.
Walker AD; Department of Pathology & Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
Hawes D; Department of Pathology & Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
Davidson TB; Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
Robison N; Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
Tamrazi B; Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
Ji J; Keck School of Medicine, University of Southern California, Los Angeles, California, United States.
Krieger MD; Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California, USA.
Cotter JA; Keck School of Medicine, University of Southern California, Los Angeles, California, United States.

Brain Pathol ; : e13297, 2024 Sep 05.

Article en En | MEDLINE | ID: mdl-39237118

ABSTRACT

ABSTRACT

Three distinct MN1BEND2 fusion-positive tumors in pediatric patients. (A) Clinical course for each patient was variable in part due to differences in initial diagnosis. Each patient responded favorably to gross total resection and is stable at last follow-up. (B) Histologic diversity, lack of prominent classical astroblastoma features, and variable immunoexpression of key markers makes microscopic diagnosis challenging.

Palabras clave

MN1::BEND2 fusion; MN1altered; RNA sequencing; astroblastoma; ependymoma; pediatric

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Pathol Asunto de la revista: CEREBRO / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

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