Impact of low birth weight on staged single-ventricle palliation.
Int J Cardiol
; : 132532, 2024 Sep 05.
Article
en En
| MEDLINE
| ID: mdl-39244099
ABSTRACT
BACKGROUND:
To assess the impact of low birth weight on early and late outcomes after staged palliation for single ventricle.METHODS:
Patients after stage 1 palliation for single ventricle in our institution were retrospectively included and divided into two weight groups 2.5â¯kg or less (low birth weight) and more than 2.5â¯kg. The impact of low birth weight on mortality and on the progression to further palliation stages (bidirectional Glenn, stage 2, and total cavopulmonary connection, stage 3) was assessed.RESULTS:
A total of 452 patients were included. Patients with low birth weight (nâ¯=â¯37, 8â¯%) had more frequently associated prematurity and extracardiac anomalies. Early and inter-stage mortality after stage 1 was higher in patients with low birth weight, so that less of these patients reached the next palliation stage (57â¯% vs. 77â¯%, pâ¯=â¯0.01, and 38â¯% vs. 56â¯%, pâ¯=â¯0.05, for stage 2 and stage 3, respectively). After 5â¯years, overall survival was inferior in patients with low birth weight (48â¯% vs. 73â¯%, pâ¯<â¯0.001). Survival conditioned by stage 2 palliation was inferior in patients with low birth weight compared to the reference group (76â¯% vs. 89â¯% after 5â¯years, pâ¯=â¯0.04). Low birth weight was a risk factor for death in most patients' subgroups, inclusive those with restricted pulmonary blood flow after a systemic-to-pulmonary shunt procedure.CONCLUSIONS:
During staged palliation of single-ventricle physiology, low birth weight has a detrimental impact on survival extending to beyond stage 2. This study calls for increased vigilance of these patients beyond the first interstage.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Int J Cardiol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos