Medicinal Perspective of 2,4-Thiazolidinediones Derivatives: An Insight into Recent Advancements.
ChemistryOpen
; : e202400147, 2024 Sep 09.
Article
en En
| MEDLINE
| ID: mdl-39246226
ABSTRACT
2,4-Thiazolidinedione derivatives represent nitrogen-containing heterocyclic compoundsâ
utilized in type 2 diabetes mellitus management. Recent advances in medicinal chemistry have unveiled diverse therapeutic potentials and structural modifications of these derivatives. This review delves into novel TZD derivatives, encompassing their synthesis, structure-activity relationships, and pharmacokinetic profiles. Various therapeutic potentials of TZDs are explored, including anticancer, antimicrobial, anti-inflammatory, antioxidant, anticonvulsant, antihyperlipidemic, anticorrosive, and antitubercular activities. Additionally, it addresses mitigating side effects associated with marketed TZD derivatives such as weight gain, oedema, fractures, and congestive heart failure in type 2 diabetes mellitus management. The review elaborates on inâ
vivo, inâ
vitro, and ex vivo studies supporting different biological activities, alongside predicting ADME and drug-likeness properties of TZDs. Computational studies are also integrated to elucidate binding modes and affinities of novel TZD derivatives. Furthermore, a plethora of novel TZD derivatives with varied and enhanced therapeutic potentials are presented, warranting further evaluation of their biological activities.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
ChemistryOpen
Año:
2024
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Alemania