Ipilimumab and nivolumab plus radioembolization as salvage therapy for atezolizumab and bevacizumab refractory hepatocellular carcinoma resulting in complete pathologic response.
Radiol Case Rep
; 19(11): 5024-5028, 2024 Nov.
Article
en En
| MEDLINE
| ID: mdl-39247469
ABSTRACT
Unresectable hepatocellular carcinoma unresponsive to first-line immunotherapy has a poor prognosis with modest response to tyrosine kinase inhibitors in the second line. In these patients, the benefit of local therapy with immunotherapy rechallenge is unknown. Radioembolization is a guideline-supported locoregional therapy for HCC that has shown the potential for synergy in combination with immunotherapy. This report describes a patient with veno-invasive HCC and extrahepatic invasion of the right kidney which progressed on atezolizumab and bevacizumab and was subsequently downstaged to resection with ipilimumab and nivolumab plus radioembolization yielding a complete pathologic response. The patient is currently more than 2 years since diagnosis without evidence of disease recurrence.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Radiol Case Rep
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos