Pd-Catalyzed Deacylative [4 + 1] Annulation of <i>N</i>-Arylimidoyl Chlorides with ß-Keto Esters Leading to 2-Fluoroalkyl Indoles.

Li, Na; Zhao, Zhi-Yi; Huang, Zi-Han; Shao, Yu-Kai; Wang, Zhao-Lun; Tu, Hai-Yong; Zhang, Xing-Guo

Pd-Catalyzed Deacylative [4 + 1] Annulation of N-Arylimidoyl Chlorides with ß-Keto Esters Leading to 2-Fluoroalkyl Indoles.

Li, Na; Zhao, Zhi-Yi; Huang, Zi-Han; Shao, Yu-Kai; Wang, Zhao-Lun; Tu, Hai-Yong; Zhang, Xing-Guo.

Afiliación

Li N; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Zhao ZY; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Huang ZH; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Shao YK; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Wang ZL; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Tu HY; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Zhang XG; College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.

J Org Chem ; 89(18): 13795-13799, 2024 Sep 20.

Article en En | MEDLINE | ID: mdl-39252666

ABSTRACT

ABSTRACT

A palladium-catalyzed [4 + 1] annulation of N-arylimidoyl chlorides with ß-keto esters has been developed. In the presence of Pd(OAc)2, PCy3, and K3PO4, a variety of fluoalkyl-containing N-arylimidoyl chlorides smoothly underwent the cascade C-H imidoylation/deacylative Heck-type reactions to afford biologically important 2-fluoroalkyl indoles in moderate to good yields.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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