Switch from methadone to buprenorphine with microinduction in outpatient setting. / Poliklinisk skifte fra metadon til buprenorfin med mikroinduksjon.
Tidsskr Nor Laegeforen
; 144(10)2024 Sep 10.
Article
en En, Nor
| MEDLINE
| ID: mdl-39254006
ABSTRACT
Background:
Switching from methadone to buprenorphine in patients receiving opioid maintenance therapy often requires inpatient care with a gradual tapering of methadone and an opioid-free day with challenging withdrawal symptoms. This case report describes and discusses a gentle outpatient approach without the opioid-free day. Case presentation A patient with a 15-year history of opioid maintenance therapy reduced his methadone dose from 80 mg to 50 mg due to concurrent use of other sedative substances and a significant risk of overdose. A week-long switch to buprenorphine 16 mg subcutaneous depot formulation was then undertaken using a microinduction approach in the outpatient setting.Interpretation:
In line with earlier reports on microinduction, the switch from methadone to buprenorphine was carried out with no opioid withdrawal symptoms or complications. Microinduction offers a smooth and more patient-friendly approach to switching from full opioid agonists to partial agonists. Randomised controlled trials are, however, needed for a systematic evaluation of this method.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Buprenorfina
/
Tratamiento de Sustitución de Opiáceos
/
Atención Ambulatoria
/
Metadona
/
Trastornos Relacionados con Opioides
Límite:
Humans
/
Male
Idioma:
En
/
Nor
Revista:
Tidsskr Nor Laegeforen
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Noruega