Association of the panimmune-inflammatory value (PIV) with all-cause and cardiovascular mortality in maintenance hemodialysis patients: a propensity score matching retrospective study.
Int Urol Nephrol
; 2024 Sep 10.
Article
en En
| MEDLINE
| ID: mdl-39254905
ABSTRACT
PURPOSE:
The panimmune-inflammatory value (PIV) is a novel inflammatory indicator. However, its role in maintenance hemodialysis (MHD) remains unclear. Our goal was to explore the predictive value of PIV for cardiovascular and all-cause mortality in MHD patients.METHODS:
In this retrospective cohort study, 507 patients receiving MHD between November 2017 and December 2022 were enrolled. The PIV value was calculated as follows neutrophil count × monocyte count × platelet count/lymphocyte count. Patients were divided into two groups on the basis of the median PIV. Propensity score matching (PSM) was used to adjust for imbalances in baseline information between groups. KaplanâMeier curves, Cox regression, the FineâGray competing risk model, and restricted cubic spline (RCS) curves were used to analyze the relationship between PIV and mortality.RESULTS:
By the end of follow-up, 126 deaths had occurred, 91 of which were due to cardiovascular disease. The KaplanâMeier curves demonstrated that MHD patients with higher PIV levels had a poorer prognosis for all-cause death (p = 0.019). PIV levels were linked to all-cause death in multivariate Cox proportional risk regression (HR = 1.76; 95% CI 1.14, 2.72; p = 0.011). The FineâGray model revealed a greater cumulative incidence of cardiovascular death in the higher PIV group (p = 0.035). PIV levels were linked to cardiovascular mortality in the FineâGray competing risk model (HR = 2.06; 95% CI 1.25, 3.42; p = 0.005). The RCS revealed a nonlinear relationship between PIV and mortality risk (p < 0.05). Using 63 years of age as the threshold, we observed a multiplicative interaction effect between age and PIV for all-cause mortality (p = 0.006).CONCLUSION:
In MHD patients, PIV is an independent hazard factor for cardiovascular-related mortality and all-cause mortality.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Int Urol Nephrol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos