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Antimicrobial Dihydroflavonols and Isoflavans Isolated from the Root Bark of Dalbergia gloveri.
Kiganda, Ivan; Wieske, Lianne H E; Nchiozem-Ngnitedem, Vaderament-Alexe; Chalo, Duncan; Umereweneza, Daniel; Ndakala, Albert; Herrebout, Wouter; Xiong, Ruisheng; Karpinski, Tomasz M; Yenesew, Abiy; Erdelyi, Mate.
Afiliación
  • Kiganda I; Department of Chemistry, University of Nairobi, P.O. BOX 30197, 30197-00100 Nairobi, Kenya.
  • Wieske LHE; Department of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
  • Nchiozem-Ngnitedem VA; Department of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
  • Chalo D; Department of Chemistry, University of Nairobi, P.O. BOX 30197, 30197-00100 Nairobi, Kenya.
  • Umereweneza D; Department of Biology, University of Nairobi, P.O. BOX 30197, 30197-00100 Nairobi, Kenya.
  • Ndakala A; Departmnet of Chemistry, College of Science and Technology, University of Rwanda, P.O. Box 3900, Kigali, Rwanda.
  • Herrebout W; Department of Chemistry, University of Nairobi, P.O. BOX 30197, 30197-00100 Nairobi, Kenya.
  • Xiong R; Department of Chemistry, University of Antwerp, 2020 Antwerp, Belgium.
  • Karpinski TM; Department of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
  • Yenesew A; Department of Medical Microbiology, Poznan University of Medical Sciences, Rokietnicka 10, 60-806 Poznan, Poland.
  • Erdelyi M; Department of Chemistry, University of Nairobi, P.O. BOX 30197, 30197-00100 Nairobi, Kenya.
J Nat Prod ; 87(9): 2263-2271, 2024 Sep 27.
Article en En | MEDLINE | ID: mdl-39255387
ABSTRACT
Three new dihydroflavonols, gloverinols A-C (1-3), a new flavon-3-ol, gloverinol D (4), two new isoflavans, gloveriflavan A (5) and B (6), and seven known compounds were isolated from the root bark of Dalbergia gloveri. The structures of the isolates were elucidated by using NMR, ECD, and HRESIMS data analyses. Among the isolated compounds, gloverinol B (2), gloveriflavan B (6), and 1-(2,4-dihydroxyphenyl)-3-hydroxy-3-(4-hydroxyphenyl)-1-propanone (10) were the most active against Staphylococcus aureus, with MIC values of 9.2, 18.4, and 14.2 µM, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Pruebas de Sensibilidad Microbiana / Raíces de Plantas / Corteza de la Planta / Dalbergia Idioma: En Revista: J Nat Prod Año: 2024 Tipo del documento: Article País de afiliación: Kenia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Staphylococcus aureus / Pruebas de Sensibilidad Microbiana / Raíces de Plantas / Corteza de la Planta / Dalbergia Idioma: En Revista: J Nat Prod Año: 2024 Tipo del documento: Article País de afiliación: Kenia Pais de publicación: Estados Unidos