Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns.
Biomark Med
; 18(15-16): 649-658, 2024 Aug 17.
Article
en En
| MEDLINE
| ID: mdl-39263780
ABSTRACT
Aim:
To evaluate the urinary biomarkers related to sepsis in preterm newborns (NBs) and to investigate the predictive capacity of these biomarkers for a longer hospital stay.Methods:
Serum and urine were collected from 27 healthy NBs, 24 NBs with neonatal infection without sepsis and 11 NBs with sepsis for the measurement of sindecan-1, lipocalin associated with urinary neutrophil gelatinase (uNGAL), urinary cystatin-C (uCysC) and urinary kidney injury molecule-1.Results:
Levels of uNGAL and urinary cystatin-C were elevated in NBs with sepsis and neonatal infection, and uNGAL was significant predictor of hospital stay longer than 30 days (odds ratio 1.052; 95% CI 1.012-1.093; p = 0.01).Conclusion:
uNGAL was associated with sepsis in preterm NBs and was useful to predict extended hospital stay.
[Box see text].
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Recien Nacido Prematuro
/
Biomarcadores
/
Sepsis
/
Cistatina C
/
Lipocalina 2
/
Tiempo de Internación
Límite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
Biomark Med
Asunto de la revista:
BIOQUIMICA
/
MEDICINA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Reino Unido