Necrotising enterocolitis suspicion in newborns with duct-dependent congenital heart disease: prognosis and risk factor.
BMJ Paediatr Open
; 8(1)2024 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-39284616
ABSTRACT
INTRODUCTION:
The main risk factors of necrotising enterocolitis (NEC) are prematurity and low birth weight. The aim of our study was to identify risk factors for NEC in patients with duct-dependent congenital heart disease (CHD). STUDYDESIGN:
Newborns with duct-dependent CHD and NEC were matched 11 to those without NEC. Matched criteria were gestational age, birth weight, antenatal versus postnatal diagnosis and type of CHD.RESULTS:
Twenty-three infants were included in each group. In the NEC group, mortality, length of intensive care unit stay and length of hospital stay were significantly higher (p=0.035; p<0.0001; p<0.0001). Lower diastolic blood pressure (DBP), negative flow balance, peritoneal dialysis and epinephrine-infusion were significantly associated with NEC (respectively, p=0.008, p=0.002, p=0.007, p=0.017). In multivariate analysis, DBP≤30 mm Hg remained the only independent risk factor of NEC (OR=8.70; 95% CI (1.46 to 53.50), p=0.019).CONCLUSION:
A DBP lower than 30 mm Hg was in our matched population of newborns with duct-dependent CHD, independently associated with NEC.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enterocolitis Necrotizante
/
Cardiopatías Congénitas
Límite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
BMJ Paediatr Open
Año:
2024
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido