Analysis of risk factors for papillary thyroid carcinoma and the association with thyroid function indicators.
Front Endocrinol (Lausanne)
; 15: 1429932, 2024.
Article
en En
| MEDLINE
| ID: mdl-39286267
ABSTRACT
Objective:
This study aims to analyze the relationship between papillary thyroid carcinoma (PTC) and various factors.Methods:
The study involved two groups-PTC patients and non-PTC controls. We utilized binary logistic regression and Least Absolute Shrinkage and Selection Operator (Lasso) regression for variable selection and risk factor analysis. Correlation analysis was performed using Spearman's rank correlation. The diagnostic value of thyroid stimulating hormone (TSH) levels for PTC was assessed using Receiver Operating Characteristic (ROC) curves.Results:
PTC patients exhibited higher body mass index (BMI) (23.71 vs. 22.66, p<0.05) and TSH levels (3.38 vs. 1.59, p<0.05). Urinary iodine concentration (UIC) was an independent predictor of PTC (OR=1.005, p<0.05). The optimal TSH threshold for PTC diagnosis was 2.4 mIU/L [The Area Under the Curve (AUC)=67.3%, specificity=71.4%, sensitivity=70.1%]. TSH levels positively correlated with BMI (r=0.593, p<0.05) and UIC (r=0.737, p<0.05).Conclusions:
UIC may be an independent predictor of PTC, and TSH levels have some diagnostic value for identifying PTC.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pruebas de Función de la Tiroides
/
Neoplasias de la Tiroides
/
Tirotropina
/
Cáncer Papilar Tiroideo
Límite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Front Endocrinol (Lausanne)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
Suiza