Uptake of fatty acids by isolated heart myocytes.
Basic Res Cardiol
; 80 Suppl 2: 107-10, 1985.
Article
en En
| MEDLINE
| ID: mdl-3933480
ABSTRACT
An adult rat heart myocyte preparation was used to study the uptake and metabolism of the 1-14C-labelled fatty acids decanoate, laurate, myristate, and palmitate. Metabolism was saturable, but free fatty acid accumulation was not. Use of metabolic inhibitors indicated that metabolism and not uptake was rate limiting at 37 degrees C and that uptake was energy dependent. Competition was demonstrated for the metabolic pathways but not for free fatty acid accumulation. The activation energy for uptake decreased with increasing fatty acid chain length. A diffusion mechanism for long chain fatty acid uptake is proposed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Grasos
/
Miocardio
Límite:
Animals
Idioma:
En
Revista:
Basic Res Cardiol
Año:
1985
Tipo del documento:
Article