11-Deoxycortisol induces hepatic tryptophan oxygenase in rats.
Acta Pharmacol Toxicol (Copenh)
; 57(1): 36-9, 1985 Jul.
Article
en En
| MEDLINE
| ID: mdl-4050454
ABSTRACT
11-Deoxycortisol (cortexolone) has previously been used as a glucocorticoid antagonist in vitro and in adrenalectomized rats. Antiglucocorticoid properties of 11-deoxycortisol in intact rats were examined by studying the effect of 11-deoxycortisol on the induction of hepatic tryptophan oxygenase (TO) by corticosterone. No antiglucocorticoid effect was observed. When 11-deoxycortisol was injected into rats, the TO activity increased. This was probably mainly caused by an elevation of the serum corticosterone level. The induction of TO by 11-deoxycortisol was inhibited by metyrapone. However, 11-deoxycortisol (100 mg/kg) was still not a glucocorticoid antagonist even in presence of metyrapone.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triptófano Oxigenasa
/
Cortodoxona
/
17-Hidroxicorticoesteroides
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
Acta Pharmacol Toxicol (Copenh)
Año:
1985
Tipo del documento:
Article