Effects of diphenylhydantoin and chloroquine on monkey liver microsomal mixed-function oxidases.
J Toxicol Environ Health
; 2(5): 1193-9, 1977 May.
Article
en En
| MEDLINE
| ID: mdl-405502
ABSTRACT
Sixteen adult male squirrel monkeys (Saimiri sciureus) were randomly divided into three treatment groups and one control group. Each treatment group received 10 mg/kg oral doses of diphenylhydantoin and/or chloroquine. Following sacrifice, in vitro assays for activity of liver microsomal mixed-function oxidases were run. The assays confirmed diphenylhydantoin as a potent inducer of mixed-function oxidases. Chloroquine administration had little affect on the enzymes assayed and did not inhibit the diphenylhydantoin induction.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
/
Fenitoína
/
Microsomas Hepáticos
/
Cloroquina
/
Oxigenasas de Función Mixta
Límite:
Animals
Idioma:
En
Revista:
J Toxicol Environ Health
Año:
1977
Tipo del documento:
Article