[Sexual hormone on the human mammary carcinoma cells in vitro (author's transl)]. / Sexualhormone auf die Kulturen menschlicher Mammakrebszellen

ABSTRACT

PIP The effects of estradiol-17 beta and testosterone on cultures of human breast cancer cells from 10 patients are described. Testosterone produced a significant decrease in the rate of cell proliferation of sex-chromatin-positive cells, while no effect of estrogen could be observed. Sex-chromatin-negative cells appeared to be independent of the 2 hormones. A significant decrease in the number of cells in cultures derived from postmenopausal patients was noted after testosterone application. Sex-chromatin-positive cells in cultures treated with either hormone were frequently abnormal in shape, with pycnotic and lytic aspects and nuclear abnormalities; sex-chromatin-negative cells showed similar abnormalities even more frequenlty.^ieng