Finite sample properties of maximum likelihood estimates of the recombination fraction in double backcross matings in man.
Am J Med Genet
; 3(1): 81-95, 1979.
Article
en En
| MEDLINE
| ID: mdl-474622
ABSTRACT
The properties of the maximum likelihood estimator (MLE) of the recombination fraction, theta, based on various numbers and sizes of sibships derived from double backcross matings are exactly explored where the coupling phases are presumed equally likely (which for two-generation data is generally the case). The results indicate that for large values of theta the expectations are severely biased. The bias, variance, and measures of normality of the MLE behave erratically for small sizes and numbers of sibships. The implications for chromosome mapping are discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Recombinación Genética
/
Consanguinidad
/
Modelos Biológicos
Límite:
Humans
Idioma:
En
Revista:
Am J Med Genet
Año:
1979
Tipo del documento:
Article