Correlation between the spermicidal activity and the haemolytic index of certain plant saponins.

ABSTRACT

The haemolytic index, the spermicidal efficacy and the effect on the vaginal mucosa of some plant saponins were determined. It was proved that a certain correlation exists between the haemolytic index and the spermicidal efficacy of these saponins. Saponin of Gypsophila paniculata was proved to be relatively superior when used in aqueous solution or when formulated in polyethylene glycol ointment base.

ABSTRACT

PIP The attempt was made to evaluate some plant saponins for their spermicidal efficiency and to correlate this efficacy with the hemolytic index of each saponin. Testing was also done for irritant behavior of these saponins and the formulation of the most effective and least irritant 1 for semisolid application. Of the tested saponins, Gypsophila paniculata saponin was found to be the most effective on human sperms. This efficient spermicidal activity was associated with a high hemolytic index and low irritant behavior. The data obtained showed a correlation between the values of the hemolytic indices and the spermicidal activity of all the plant saponins except that of Terminalia horrida.