Pharmacokinetics of azapropazone following single oral and intravenous doses.
Arzneimittelforschung
; 29(6): 971-2, 1979.
Article
en En
| MEDLINE
| ID: mdl-582795
ABSTRACT
The pharmacokinetics of azapropazone (Prolixan) was studied in 7 healthy volunters following single oral and i.v. doses of 600 mg. After i.v. injection plasma concentration declined biexponentially with time. The half-life of the beta-phase was 13.6 +/- 2.6 h (mean +/- SD), the apparent volume of distribution 11.9 +/- 3.5 l, and the total clearance 10.1 +/- 2.1 ml . min-1. Following oral administration peak plasma concentrations occurred between 3 and 6 h and declined with a beta-phase half-life of 14.3 +/- 2.8 h. The binding of azapropazone to plasma proteins was high (ranging from 99.52 to 99.67% at a total plasma concentration of 75 micrograms/ml). The bioavailability of azapropazone when administered as capsules was 83 +/- 19%.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triazinas
/
Apazona
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Arzneimittelforschung
Año:
1979
Tipo del documento:
Article