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Nephronophthisis with massive proteinuria.
Am J Kidney Dis ; 2(6): 640-4, 1983 May.
Article en En | MEDLINE | ID: mdl-6189393
A 23-year-old male whose uncle died of nephronophthisis, and whose pathology is also discussed, presented with 5 g of protein in a 24-hour urine collection. Nephrogenic diabetes insipidus and salt wasting were present in addition to azotemia. Characterization of the proteinuria, including elevated alpha globulins by electrophoresis and markedly elevated urinary beta-microglobulins by radioimmunoassay (49.55 mg/L) indicated predominantly tubular proteinuria. A percutaneous renal biopsy showed normal glomeruli, interstitial inflammation and fibrosis, and tubular atrophy. Electron microscopy revealed notable alterations of the tubular basement membrane.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteinuria / Enfermedades Renales Quísticas / Enfermedades Renales Límite: Adult / Humans / Male Idioma: En Revista: Am J Kidney Dis Año: 1983 Tipo del documento: Article Pais de publicación: Estados Unidos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteinuria / Enfermedades Renales Quísticas / Enfermedades Renales Límite: Adult / Humans / Male Idioma: En Revista: Am J Kidney Dis Año: 1983 Tipo del documento: Article Pais de publicación: Estados Unidos