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[Comparative elimination of pirprofen from the plasma and synovial fluid of the knee. 26 cases]. / Elimination comparée du pirprofène à partir du plasma et du liquide synovial du genou. 26 observations.
Presse Med ; 12(33): 2045-7, 1983 Sep 24.
Article en Fr | MEDLINE | ID: mdl-6226019
Twenty-six patients with various inflammatory diseases of the knee were treated with a 400 mg dose of pirprofen orally twice a day for 2 days. On the third day, samples of blood and synovial fluid were taken 3 h and 10 h approximately after a fifth 400 mg dose of the drug. Pirprofen concentrations, as determined by gas-liquid chromatography, were higher in plasma than in synovial fluid during the 2-5 h period post-dosing. They decreased with an elimination half-life of 6 h in plasma as against 41 hours in synovial fluid. This study demonstrates that pirprofen diffuses into the synovial fluid where it remains significantly longer than in plasma.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenilpropionatos / Líquido Sinovial / Antiinflamatorios no Esteroideos Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: Fr Revista: Presse Med Año: 1983 Tipo del documento: Article Pais de publicación: Francia
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenilpropionatos / Líquido Sinovial / Antiinflamatorios no Esteroideos Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: Fr Revista: Presse Med Año: 1983 Tipo del documento: Article Pais de publicación: Francia