Correlation between the dose and development of acute tolerance to the hypothermic effect of THC.
Pharmacology
; 21(6): 391-5, 1980.
Article
en En
| MEDLINE
| ID: mdl-6261269
ABSTRACT
The administration of 0.3-40 mg/kg delta 9-tetrahydrocannabinol (THC) produced a dose-dependent hypothermia in rats. The maximal hypothermic effect was obtained with the dose of 2.5 mg/kg of THC. When the same doses of THC were repeated on days 2 and 3, tolerance to the hypothermic effect of THC was apparent. Doses of THC higher than 2.5 mg/kg induced a significant and dose-dependent tolerance after the first administration whereas with the lower doses, tolerance was only apparent after the second injection. The possible mechanism of these effects of THC is discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dronabinol
/
Hipotermia
Límite:
Animals
Idioma:
En
Revista:
Pharmacology
Año:
1980
Tipo del documento:
Article