Clinical relevance of PM-1 antibody and physiochemical characterization of PM-1 antigen.
J Rheumatol
; 11(5): 658-62, 1984 Oct.
Article
en En
| MEDLINE
| ID: mdl-6334745
ABSTRACT
Using an improved immunodiffusion test with partially purified antigen, PM-1 antibody was identified in the serum of 18 patients. In 67% this system was associated with a polymyositis-scleroderma overlap, it occurred less frequently in polymyositis, dermatomyositis and scleroderma, and was not detected in other rheumatic diseases. The predominant clinical features of PM-1 positive patients were muscle weakness, sclerodactyly, Raynaud's phenomenon and pulmonary disease; widespread sclerodermatous features with infrequent. Characterization of the PM-1 antigen showed it to be a heat sensitive, trypsin sensitive acidic protein associated with the cell nucleus and possibly with nucleoli.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ribonucleoproteínas
/
Esclerodermia Sistémica
/
Autoantígenos
/
Anticuerpos Antinucleares
/
Ribonucleoproteínas Nucleares Pequeñas
/
ARN Citoplasmático Pequeño
/
Miositis
/
Antígenos
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Rheumatol
Año:
1984
Tipo del documento:
Article