The mutagenicity and cytotoxicity of selenite, "activated" selenite and selenate for normal and DNA repair-deficient human fibroblasts.
Mutat Res
; 49(3): 305-12, 1978 Mar.
Article
en En
| MEDLINE
| ID: mdl-634305
ABSTRACT
At doses varying from 8 x 10(-5) to 3 x 10(-3) M sodium selenite (Na2SeO3) induced DNA fragmentation, DNA-repair synthesis, chromosome aberrations and a mitotic inhibition in cultured human fibroblasts. The response of DNA repair-deficient xeroderma pigmentosum (XP) fibroblasts to selenite is comparable to that of control cells. Incubation with mouse liver S-9 microsomal fraction increased the capacity of selenite to induce chromosome aberrations, DNA-repair synthesis and a lethal effect. XP cells behaved as control cells when treated with activated selenite. Sodium selenate (Na2SeO4) at doses ranging from 8 x 10(-5) to 3 x 10(-3) M could not be activated by incubating with a S-9 preparation. Selenate had the capacity to induce a small but significant DNA-repair synthesis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Selenio
/
Piel
/
Xerodermia Pigmentosa
/
Mutágenos
Límite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Mutat Res
Año:
1978
Tipo del documento:
Article