Transfer of phosphatidylcholine facilitated by a component of human plasma.

ABSTRACT

A constituent of lipoprotein-free (p greater than 1.21) human plasma from normolipemic donors facilitates the transfer of diacyl phosphatidylcholine from unilamellar egg yolk phosphatidylcholine liposomes to liver mitochondria. The active component is heat labile, has a hydrated density greater than 1.25 and an apparent molecular weight of more than 100 000. The presence of this protein in plasma may facilitate movement of diacylphospholipids between the surfaces of lipid-containing particles such as lipoproteins and erythrocytes. Knowledge of the properties and behavior of this protein are important in designing methods of drug therapy based on encapsulation in biodegradable lipid vesicles.