Effect of nomifensine on the toxicity of 6-hydroxydopamine for mesotelencephalic dopamine neurons.
Brain Res
; 308(1): 155-8, 1984 Aug 06.
Article
en En
| MEDLINE
| ID: mdl-6434148
ABSTRACT
The ability of nomifensine to protect the dopaminergic cells of the substantia nigra and ventral tegmental areas against 6-hydroxydopamine-induced destruction was evaluated. Nomifensine at high doses (20 mg/kg, i.p.) protected the cells from the effects of low amounts of 6-hydroxydopamine (2 micrograms) injected intracerebrally. This protective effect was markedly decreased with an increased amount of 6-hydroxydopamine (8 micrograms), or by lower doses of nomifensine (6.7 mg/kg). These doses of nomifensine are higher than those required to protect dopaminergic nerve terminals.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Telencéfalo
/
Sustancia Negra
/
Dopamina
/
Nomifensina
/
Hidroxidopaminas
/
Isoquinolinas
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1984
Tipo del documento:
Article