HeLa cell tumor response to 60Co, Cs-137, Cf-252 radiations and cisplatin chemotherapy in nude mice.
Cancer
; 54(2): 247-52, 1984 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-6539162
ABSTRACT
HeLa cells were implanted into athymic nude mice from tissue culture and solid tumors established (HeLa cell tumor or HCT). Large cell numbers of 1 X 10(7) were required to obtain consistent and progressive growth, and tumor growth followed a Gompertzian mode. Irradiation studies were carried out using acute Cobalt-60 (60Co), low-dose-rate (LDR) Cs-137 and LDR Cf-252. Cf-252, a neutron-emitting radioisotope, produced an immediate tumor shrinkage and regression response after a dose of 279 cGy. Acute 60Co or LDR Cs-137 irradiation with 1000 cGy had little effect on the HCT. After a dose of 2000 cGy of 60Co radiation tumor shrinkage followed a latent period of approximately 5 days. Cisplatin had no effect on the HCT in nude mice in stationary or late exponential growth.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células HeLa
/
Radioisótopos de Cesio
/
Californio
/
Cisplatino
/
Radioisótopos de Cobalto
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Cancer
Año:
1984
Tipo del documento:
Article