Pharmacological studies on carbapenem antibiotics. II. Isolation of a PS-5-inactivating factor from the rat kidney.
J Antibiot (Tokyo)
; 35(6): 729-35, 1982 Jun.
Article
en En
| MEDLINE
| ID: mdl-6811539
ABSTRACT
A factor responsible for the in vivo metabolism of PS-5 was isolated from the microsomal fraction of the rat kidney. This factor, which did not attack penicillins and cephalosporins, was enzymologically identified with particle-bound renal dipeptidase. Under the action of this factor, PS-5 was inactivated to give three products designated PS-5D I, PS-5D II and PS-5D III.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tienamicinas
/
Dipeptidasas
/
Riñón
/
Antibacterianos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
1982
Tipo del documento:
Article