[Preclinical studies of Pharmachem's teravit]. / Niakoi predklinichni izsledvaniia na teravit "Farmakhim".

ABSTRACT

Studied was the preparation Teravit Pharmachim in terms of its physical and chemical properties, antimicrobial activity, resorption, retention, and distribution, within the body of chickens and albino rats. It was found that Teravit Pharmachim was strongly sensitive to light, slightly hygroscopic, and relatively heat resistant. It showed good antimicrobial activity with regard to both Gram-positive and Gram-negative organisms. At 60-day feed application to albino rats at the rates of 30 and 300 mg/kg it stimulate the growth of test animals, and at the rate of 1500 mg/kg it delayed their development but did not produce negative effects on the red and white blood picture. Teravit Pharmachim was shown to bind the proteins of the body liquids and tissues, which depended on the biologic substrate and the antibiotic concentration. At the single oral application (chickens) or the administration with feed in the course of 60 days (albino rats) Teravit Pharmachim was resorbed depending on the dose, was retained in the blood, and was further followed up in the internal organs. It was eliminated from the body for about 3 to 5 days, did not cumulate in the ovarian follicles, and was not excreted with the eggs.