Investigation of insulin sensitivity in early diabetes. I. Procedure for the determination of insulin responsiveness in vivo.
Endokrinologie
; 75(1): 98-104, 1980 Jan.
Article
en En
| MEDLINE
| ID: mdl-6989594
ABSTRACT
Twenty-three normal weight subjects without any heredity of diabetes were characterized by a 2-hour glucose infusion test. All persons showed a normal carbohydrate tolerance and normal biphasic insulin secretion pattern. For the determination of insulin sensitivity a 1-hour priming dose--constant infusion technique was used. Two 30-minute-periods of insulin infusion (8 and 16 mU/kg, primed by a start injection of 1 and 2 mU/kg, respectively) provoked a decrease of plasma glucose and FFA concentrations by 35 +/- 12.5% and 55 +/- 30.2%, respectively. Values lower than 22.5% (glycemia) or 25% (FFA) indicate a diminished insulin responsiveness. The metabolic clearance rate of insulin did not change at several concentrations of IRI. Thus, the proposed procedure is suitable to study the insulin sensitivity in vivo.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estado Prediabético
/
Glucemia
/
Prueba de Tolerancia a la Glucosa
/
Insulina
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Endokrinologie
Año:
1980
Tipo del documento:
Article