Mathematical analysis of 51Cr-labelled red cell survival curves in congenital haemolytic anaemias.
Eur J Nucl Med
; 7(4): 181-3, 1982.
Article
en En
| MEDLINE
| ID: mdl-7075620
ABSTRACT
The parameters of 51Cr labelled red cell survival curves were calculated in 33 patients with homozygous beta-thalassaemia, 8 with sickle-cell anaemia and 3 with s -- beta-thalassaemia, using a non-linear weighted least squares analysis computer program. In thalassaemic children the calculated parameters denote that the shortening of the mean cell life is due to early senescence alone, while there is some evidence that in thalassemic adults additional extracellular destruction mechanisms participate as well. Red cell survival curves from patients with sickle-cell anaemia and s -- beta-thalassaemia resemble each other, while their parameters indicate an initial rapid loss of radioactivity, early senescence and the presence of extracellular red cell destruction factors.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Radioisótopos de Cromo
/
Envejecimiento Eritrocítico
/
Eritrocitos
/
Anemia Hemolítica Congénita
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Eur J Nucl Med
Año:
1982
Tipo del documento:
Article