[Modification of the nigro-striatal system by estrogens and prolactin. Clinical and experimental data]. / Modulazione del sistema nigrico-striatale da parte di estrogenie prolattina. Dati clinici e sperimentali.
Boll Soc Ital Biol Sper
; 58(16): 1054-60, 1982 Aug 30.
Article
en It
| MEDLINE
| ID: mdl-7138674
ABSTRACT
We have investigated the effects of estrogens and prolactin on nigro-striatal dopaminergic function. In this regard, apomorphine-induced hyperactivity has been evaluated in hyperprolactinemic rats. Results obtained suggest the possibility that hyperprolactinemia potentiates nigro-striatal dopaminergic transmission inducing, in chronic, charges in dopamine receptor sensitivity. As a neurochemical parameter of the extrapyramidal motor system, we have investigated the activity of the GABA-synthesizing enzyme glutamate decarboxylase (GAD, EC 4.1.1.15) in corpus striatum and substantia nigra. Hyperprolactinemia induced by anterior pituitary homograft under the kidney capsule or systemic sulpiride injection significantly increases GAD activity. In contrast, estrogen treatment decreases nigral GAD activity even though increases plasma prolactin levels. From a clinical point of view, preliminary data indicating a good therapeutical efficacy of estrogens and progesterone in psychiatric patients are reported.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prolactina
/
Sustancia Negra
/
Cuerpo Estriado
/
Estrógenos
Límite:
Animals
Idioma:
It
Revista:
Boll Soc Ital Biol Sper
Año:
1982
Tipo del documento:
Article
Pais de publicación:
IT
/
ITALIA
/
ITALY
/
ITÁLIA