A bioequivalence study of three preparations of propranolol.
J Clin Hosp Pharm
; 7(4): 281-6, 1982 Dec.
Article
en En
| MEDLINE
| ID: mdl-7161403
ABSTRACT
The bioequivalence of two different tablets and a solution, each containing 10 mg propranolol hydrochloride was studied in twelve healthy volunteers. Single oral doses of each preparation were administered at intervals of one week. Samples of blood for propranolol radioimmunoassay were taken up to 8 h after dosing. The plasma propranolol concentration at 0.5 h was significantly higher for the solution than for the two tablet formulations which did not differ significantly from each other at any sampling point. The area under the curve was similar for all three preparations. The study demonstrated that the three different preparations of propranolol were bioequivalent.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Propranolol
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Hosp Pharm
Año:
1982
Tipo del documento:
Article