[Activation of GABA system metabolism in the cerebral hemispheres during exposure to different stress factors]. / Aktivatsiia metabolizma GAMK-sistemy v polushariiakh golovnogo mozga pri deistvii razlichnykh stressornykh faktorov.

ABSTRACT

The paper concerns the basic parameters of GABA metabolism in 4 groups of animals after emotional pain stress; after twofold administration of formalin; after coronary artery ligation; after narrowing of the aorta ostium. GABA metabolism in all brain systems was shown to be activated in all types of exposure to stress. One of the final GABA metabolites, hydroxybutyric acid, prevents undue enhancement of pituitary-adrenal function and injury to the internal organs during stress. This suggests that the GABA-ergic system plays the role of a nonspecific inhibitory mechanism that limits the stress-syndrome and averts stress injuries under exposure of the body to various extreme factors.