[Increase in novobiocin activity and an expansion of its antimicrobial action spectrum]. / Povyshenie aktivnosti novobiotsina i rasshirenie spektra ego antimikrobnogo deistviia.

ABSTRACT

It was found that with an increase in the medium acidity (pH 6.0 - 6.2) the antistaphylococcal effect of novobiocin significantly rose and the drug began to inhibit gram-negative bacteria, in particular, P. aeruginosa and Proteus. The method efficacy was demonstrated on a limited number of patients with urological infections caused by P. aeruginosa and increased acidity of the urine (because of cranberry juice use). Wider observations in patients with urological and some other diseases caused by gram-negative bacteria are advisable.