Suction blister fluid as a model for interstitial fluid in rats.
Arch Dermatol Res
; 263(3): 325-4, 1978 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-742910
ABSTRACT
1. Suction blisters on the skin of rats, obtained with a negative pressure of 150 mm Hg, show a close similarity to human suction blisters, based on histological, electrolyte and protein findings. 2. Pharmacokinetic experiments with inulin and antipyrine have proved that the movement of these low protein binding drugs between blister fluid and serum follows the laws of diffusion. 3. The investigations suggest that blister fluid resembles interstitial fluid and can therefore serve as a model for the estimation of drug concentrations in interstitial fluid.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vesícula
/
Modelos Animales de Enfermedad
/
Espacio Extracelular
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Arch Dermatol Res
Año:
1978
Tipo del documento:
Article