Immunogenicity of the yeast recombinant p17/p24:Ty virus-like particles (p24-VLP) in healthy volunteers.
Vaccine
; 13(9): 831-4, 1995 Jun.
Article
en En
| MEDLINE
| ID: mdl-7483805
ABSTRACT
In this Phase I study, immunisation with the yeast-derived p24 virus-like particles Ty p24-VLP (3 x 100 or 3 x 500 micrograms subcutaneously) in 16 healthy male subjects elicited p24 antibody responses in 4 of 16 (25%) subjects. After a fourth, intramuscular, immunisation (500 micrograms), p24 antibody responses were detected in 11 of 15 (70%) subjects. In addition to p24 antibody responses, T cell proliferative responses were also observed, although no HLA restricted p24-specific cytotoxic T cell responses were detected. The results demonstrate that Ty p24-VLP is immunogenic and well-tolerated in healthy male subjects.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Virales
/
Antígenos VIH
/
Productos del Gen gag
/
Infecciones por VIH
/
VIH
/
Proteína p24 del Núcleo del VIH
/
Vacunas contra el SIDA
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Vaccine
Año:
1995
Tipo del documento:
Article
País de afiliación:
Reino Unido