Platinum salt sensitivity in refinery workers: incidence and effects of smoking and exposure.
Occup Environ Med
; 52(10): 661-6, 1995 Oct.
Article
en En
| MEDLINE
| ID: mdl-7489056
ABSTRACT
OBJECTIVE:
To measure the incidence of platinum salt sensitivity (PSS) in refinery workers and examine the influence of cigarette smoking and exposure to platinum salts on sensitisation.DESIGN:
A prospective cohort study with examination of workers at quarterly intervals for 18 months, and again at 24 months.SETTING:
A South African primary platinum refinery.SUBJECTS:
78 new recruits, selected by the refinery's usual procedure, without apparent atopy and in good respiratory health.RESULTS:
After 24 months 32 (41%) subjects had been diagnosed PSS and were subsequently medically separated. Twenty two (28%) cases were confirmed by positive skin prick test to platinum salts, 10 (13%) cases were symptomatic but skin prick negative. Incidence of cases per 100 person-months was 1.9 skin prick positive and 0.8 negative. Risk of sensitisation was about eight times greater for smokers than non-smokers, and six times greater for high exposure than low exposure.CONCLUSION:
Smoking and intensity of exposure were definitely associated with development of PSS. Positive responses to platinum salt skin prick test had a 100% positive predictive value for symptoms and signs of PSS if exposure continued.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fumar
/
Exposición Profesional
/
Compuestos de Platino
/
Hipersensibilidad
/
Metalurgia
/
Enfermedades Profesionales
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
Occup Environ Med
Asunto de la revista:
MEDICINA OCUPACIONAL
/
SAUDE AMBIENTAL
Año:
1995
Tipo del documento:
Article
País de afiliación:
Sudáfrica