The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon.
J Virol
; 69(12): 8147-50, 1995 Dec.
Article
en En
| MEDLINE
| ID: mdl-7494339
ABSTRACT
The injection of 20 ng of mouse interleukin-12 (IL-12) protects mice from a lethal infection with encephalomyocarditis virus. In vitro, an anti-gamma interferon (anti-IFN-gamma) monoclonal antibody but not an anti-IL-12 monoclonal antibody neutralizes the antiviral activity present in the supernatants of splenocytes stimulated with IL-12. Finally, IL-12 fails to protect 129 Sv/Ev IFN-gamma R0/0 mice against encephalomyocarditis virus infection. These results demonstrate that IL-12 exerts its antiviral activity through the induction of endogenous IFN-gamma.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Interferón gamma
/
Infecciones por Cardiovirus
/
Interleucina-12
/
Virus de la Encefalomiocarditis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Virol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Suiza