The expression of FMS, KIT and FLT3 in hematopoietic malignancies.
Leuk Lymphoma
; 13(3-4): 223-7, 1994 Apr.
Article
en En
| MEDLINE
| ID: mdl-7519507
ABSTRACT
Three receptor molecules, belonging to the class III of receptor tyrosine kinases, namely the receptors for colony-stimulating factor 1, CSF1R (product of the FMS proto-oncogene) and Steel factor, SLFR (product of the KIT proto-oncogene), as well as the recently identified FLT3/FLK2 gene product, appear to play distinct roles in normal hematopoietic differentiation. Their potential role in leukemic hematopoiesis has been approached by expression studies in hematopoietic malignancies, especially in acute leukemias of the myeloid and lymphoid lineages. We present here a review of available data, and discuss the possible significance and potential applications of these results.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia
/
Regulación Leucémica de la Expresión Génica
/
Factores de Crecimiento de Célula Hematopoyética
/
Factor Estimulante de Colonias de Macrófagos
/
Proteínas Proto-Oncogénicas
/
Proteínas Tirosina Quinasas Receptoras
/
Receptores de Superficie Celular
/
Proteínas de Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Leuk Lymphoma
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
Año:
1994
Tipo del documento:
Article
País de afiliación:
Francia