Substance P: endothelial localization and pharmacology in the human ovarian vein.
Obstet Gynecol
; 85(2): 273-8, 1995 Feb.
Article
en En
| MEDLINE
| ID: mdl-7529915
ABSTRACT
OBJECTIVE:
To investigate the possible role of substance P as an endothelial factor in the local regulation of vascular tone in the human ovarian vein.METHODS:
We performed immunolocalization of substance P in human ovarian venous endothelium in situ and in culture, and observed responses to substance P in preconstricted ring preparations of human ovarian vein in the presence of either the prostaglandin synthesis inhibitor indomethacin or the inhibitor of nitric oxide synthesis L-nitro arginine methyl ester (L-NAME), with and without luminal rubbing.RESULTS:
Substance P was localized in a subpopulation of ovarian vein endothelial cells. Maximal relaxation induced by substance P was not significantly affected by indomethacin (10 mumol/L), but was reduced from 58.7% (95% confidence interval [CI] 41.3-76.1) in control experiments to 24.7% (95% CI 18.3-31.1) after luminal rubbing and to 32.3% (95% CI 19.8-44.8) after exposure to L-NAME (0.1 mmol/L) (P = .001).CONCLUSION:
The localization of substance P in ovarian vein endothelium together with vasodilator effects mediated partially via the endothelium suggests that the peptide has a role in the local control of vascular tone in this vessel.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ovario
/
Endotelio Vascular
/
Sustancia P
Límite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Obstet Gynecol
Año:
1995
Tipo del documento:
Article