A neutrophil-derived NO-synthase (NOS) inhibitor.
Agents Actions Suppl
; 45: 163-8, 1995.
Article
en En
| MEDLINE
| ID: mdl-7536383
ABSTRACT
In the present work we have demonstrated that the low NOS activity of circulating blood neutrophils is related to an endogenous inhibitory factor. This factor inhibits constitutive NOS (cNOS) of cerebellum and inducible NOS (iNOS) of macrophages in a concentration-dependent manner. Boiling only partially diminished its activity. The inhibition of cNOS was specific, since to some degree NADPH (0.5-4 mM) and more effectively L-arginine (0.1-1 mM), but not D-arginine, reversed the inhibition.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aminoácido Oxidorreductasas
/
Neutrófilos
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Agents Actions Suppl
Año:
1995
Tipo del documento:
Article
País de afiliación:
Polonia