CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses.
Gene Ther
; 2(2): 132-7, 1995 Mar.
Article
en En
| MEDLINE
| ID: mdl-7536617
The ability to program recombinant gene expression in specific sets of motor and sensory neurons would facilitate the treatment of a number of acquired and inherited central nervous system (CNS) diseases. In this report, we demonstrate that intramuscular injection of replication-defective recombinant adenovirus results in high-level recombinant gene expression, specifically in the CNS motor and sensory neurons that innervate the inoculated muscles. Neural expression of the recombinant genes results from virus transport into the CNS, presumably by retrograde axonal transport. This novel method of neural gene delivery may be of value in studies designed to improve understanding and treatment of inherited and acquired neurological diseases.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Médula Espinal
/
Transporte Axonal
/
Nervio Tibial
/
Tronco Encefálico
/
Ventrículos Cerebrales
/
Adenoviridae
/
Virus Defectuosos
/
Vectores Genéticos
/
Nervio Hipogloso
Límite:
Animals
Idioma:
En
Revista:
Gene Ther
Asunto de la revista:
GENETICA MEDICA
/
TERAPEUTICA
Año:
1995
Tipo del documento:
Article
Pais de publicación:
Reino Unido