B7.2 provides co-stimulatory functions in vivo in response to staphylococcal enterotoxin B.
Eur J Immunol
; 25(7): 2111-4, 1995 Jul.
Article
en En
| MEDLINE
| ID: mdl-7542606
ABSTRACT
Excessive T cell activation induced by bacterial superantigens plays an important role in the pathology associated with Gram-positive bacteremia. To gain insight into the early phases of T cell activation by bacterial enterotoxins in vivo, we investigated the ability of antibodies to well-defined co-stimulatory molecules to inhibit T cell activation and the subsequent toxic shock syndrome induced in BALB/c mice following the injection of staphylococcal enterotoxin B (SEB). We demonstrate here that a single dose of anti-B7.2 antibodies, but not anti-B7.1 antibodies, significantly inhibits T cell activation, as judged by lower systemic IL-2 release, blastogenesis and IL-2 receptor expression, and reduces the lethal effect of SEB in D-galactosamine-sensitized mice. These results demonstrate that co-stimulation through the B7.2 molecule plays an important role in the activation of T cells in response to SEB in vivo and suggest alternative therapies for septic shock caused by bacterial enterotoxins based on blocking antibodies to co-stimulatory molecules.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Linfocitos T
/
Antígenos CD
/
Antígeno B7-1
/
Enterotoxinas
Límite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Bélgica