Serum IgG, IgM, and IgA reactivity to human papillomavirus types 11 and 6 virus-like particles in different gynecologic patient groups.
J Infect Dis
; 172(2): 395-402, 1995 Aug.
Article
en En
| MEDLINE
| ID: mdl-7542685
ABSTRACT
Serum samples from several groups of patients attending a gynecology clinic were analyzed by ELISA for specific antibodies recognizing surface epitopes on intact human papillomavirus (HPV) types 6 and 11 L1 virus-like particles (VLPs) that were synthesized in vitro. In these samples, positive IgG and IgM reactivities to HPV-11 L1 VLPs were, respectively, 12% and 6% for 87 controls, 46% and 67% for 79 condyloma patients, 30% and 64% for 72 cervical intraepithelial neoplasia patients, 16% and 19% for 63 pregnant women at time of delivery, and 5% and 0 in their 63 newborns. IgA reactivities were low and not significantly different. The prevalence of IgG-positivity in HPV-6/11 DNA-positive patients increased from 46% with HPV-11 L1 VLPs to 76% when the sera were additionally screened with HPV-6 L1 VLPs. These data show that HPV-6 and -11 L1 VLPs are effective antigens for serologic studies and they detect type-specific antibodies.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virión
/
Proteínas Oncogénicas Virales
/
Cápside
/
Infecciones por Papillomavirus
/
Proteínas de la Cápside
/
Enfermedades de los Genitales Femeninos
/
Anticuerpos Antivirales
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
J Infect Dis
Año:
1995
Tipo del documento:
Article
País de afiliación:
Austria